Meta-Analysis: Risk of Dementia Up in Type 2 Diabetes

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Meta-Analysis: Risk of Dementia Up in Type 2 Diabetes
Meta-Analysis: Risk of Dementia Up in Type 2 Diabetes

(HealthDay News) — The risk of dementia is increased for individuals with type 2 diabetes, and the additional risk of vascular dementia, but not nonvascular dementia, is greater in women than in men, according to a meta-analysis published online December 17 in Diabetes Care.

Saion Chatterjee, from Alfred Health in Melbourne, Australia, and colleagues conducted a meta-analysis to examine the sex-specific relationship between women and men with diabetes and incident dementia. Data were included from 14 studies, with 2 310 330 individuals and 102 174 dementia case patients.

The researchers found that diabetes correlated with an increased risk of any dementia in both sexes (women: pooled relative risk [RR], 1.62; men: pooled RR, 1.58), in multiple-adjusted analyses. For vascular dementia, the diabetes-associated RRs were 2.34 in women and 1.73 in men; the corresponding RRs were 1.53 and 1.49 for nonvascular dementia. Compared with men, women with diabetes had an increased risk for the development of vascular dementia (multiple-adjusted ratio of RRs, 1.19; P<0.001).

"Individuals with type 2 diabetes are at 60% greater risk for the development of dementia compared with those without diabetes," the authors write. "For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women."

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