Maternal Age at Menopause Tied to Daughter's Ovarian Reserve
(HealthDay News) – Women whose mothers naturally went through menopause at an early age may have advanced depletion of ovarian reserve compared with women whose mothers had late menopause.
Janne G. Bentzen, MD, PhD, from Copenhagen University Hospital in Denmark, and colleagues examined the association between markers of ovarian reserve (serum anti-Müllerian hormone [AMH] levels and antral follicle count [AFC]) and the age of onset of natural maternal menopause in 527 women aged 20–40 years old. Early maternal menopause was defined as occurring at <45 years old, normal maternal menopause at 46–54 years old, and late menopause at >55 years old.
The researchers found that median serum AMH levels fell annually by 8.6% in the group with early maternal menopause, by 6.8% in those with normal maternal menopause, and by 4.2% in those with late maternal menopause. Median AFC levels showed a similar pattern, falling annually by 5.8% for women with early maternal menopause, by 4.7% for those with normal maternal menopause, and by 3.2% for those with late maternal menopause.
"This paper shows that early maternal menopause is related to an advanced depletion of the ovarian reserve and that late maternal menopause is related to a delayed depletion," Bentzen and colleagues conclude.