Lowering Cholesterol Doesn't Aid Renal Progression
(HealthDay News) — Lowering low-density lipoprotein (LDL) cholesterol in patients with chronic kidney disease (CKD) does not significantly benefit renal progression, according to a study published online May 1 in the Journal of the American Society of Nephrology.
Richard Haynes, BM, BCh, from the University of Oxford in the United Kingdom, and other SHARP (Study of Heart and Renal Protection) investigators randomly assigned 6,245 patients with CKD (not on dialysis) to simvastatin 20mg plus ezetimibe 10mg daily or matching placebo.
The researchers found that, over 4.8 years of follow-up, simvastatin plus ezetimibe resulted in an average LDL cholesterol difference of 0.96mmol/L compared with placebo. The incidence of end-stage renal disease (ESRD) was reduced nonsignificantly by 3% (33.9% of cases in the treatment arm vs. 34.6% of cases with placebo; P=0.41). Treatment had no significant effect on the pre-specified tertiary outcomes of ESRD or death (P=0.34) or of ESRD or doubling of baseline creatinine (P=0.09). No significant effect on the rate of change in estimated glomerular filtration rate was seen in exploratory analyses.
"Lowering LDL cholesterol by 1mmol/L did not slow kidney disease progression within five years in a wide range of patients with CKD," the authors write.
The study was funded by Merck/Schering-Plough Pharmaceuticals.