Low Inflammatory Status Linked to Metabolic Health in Obese
(HealthDay News) – Metabolic health is associated with favorable inflammatory status in both obese and non-obese individuals, according to a study published online Aug. 26 in the Journal of Clinical Endocrinology & Metabolism.
Using data from a cross-sectional sample of 2,047 men and women aged 45–74 years, Catherine M. Phillips, PhD, and Ivan J. Perry, PhD, from University College Cork in Ireland, and colleagues examined the extent to which differences in metabolically healthy and unhealthy obese and non-obese adults correlate with inflammatory markers. Metabolic health status was defined using five existing definitions based on cardiometabolic abnormalities.
The researchers found that, compared with metabolically unhealthy participants, metabolically healthy obese and non-obese individuals had lower concentrations of complement component 3 (C3), C-reactive protein, tumor necrosis factor-α, interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), and white blood cells (WBCs), while adiponectin levels were higher. The likelihood of metabolically healthy obesity was significantly increased for those with lower levels of C3, IL-6, PAI-1, WBCs, and with higher concentrations of adiponectin.
"Favorable inflammatory status is positively associated with metabolic health in obese and non-obese individuals," the authors write. "These findings are of public health and clinical significance in terms of screening and stratification based on metabolic health phenotype to identify those at greatest cardiometabolic risk for whom appropriate therapeutic or intervention strategies should be developed."