Long-Term Mortality Risk Low After Cerebral Vein Thrombosis

Long-Term Mortality Risk Low After Cerebral Vein Thrombosis
Long-Term Mortality Risk Low After Cerebral Vein Thrombosis

(HealthDay News) – For patients who survive a cerebral vein thrombosis (CVT), the long-term risk of mortality and recurrent venous thromboembolism (VTE) seems to be low.

Francesco Dentali, MD, from the University of Insubria in Varese, Italy, and colleagues retrospectively assessed long-term mortality rates, residual disability, and recurrent VTE in an international cohort of 706 patients (73.7% female) with a first CVT episode who were followed for a median of 40 months (range, 6–297 months).

Over the follow-up period, the researchers found that 2.8% of patients died, 89.1% had a complete recovery (modified Rankin Score [mRS], 0–1), and 3.8% had a partial recovery and were independent (mRS, 2). The mean treatment duration was 12 months, during which time 84% of patients were treated with oral anticoagulants. CVT recurred in 4.4% of patients, and 6.5% had VTE in a different site, corresponding with an overall incidence of recurrence of 23.6 events per 1,000 patient-years and of 35.1 events per 1,000 patient years after anticoagulant therapy withdrawal. The only significant predictor of recurrence in multivariate analysis was a previous VTE (hazard ratio, 2.70).

"The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT," the authors write.

Abstract
Full Text (subscription or payment may be required)