Long-Detection Interval for ICD Has Favorable Results

Long-Detection Interval for ICD Has Favorable Results
Long-Detection Interval for ICD Has Favorable Results

(HealthDay News) — A long-detection interval for implantable cardioverter-defibrillators (ICDs) is associated with favorable results in terms of hospitalization and costs, according to a research letter published in the Aug. 6 issue of the Journal of the American Medical Association.

Alessandro Proclemer, MD, from the Azienda Ospedaliera Universitaria S. Maria della Misericordia in Udine, Italy, and colleagues examined the association of programing a long-detection interval for ICDs on hospitalization, length of hospital stay, and costs. Data were extracted from the Avoid Delivering Therapies for Non-sustained Arrhythmias in ICD Patients III (ADVANCE III). Patients were followed for one year after receiving their first ICD, which was programed to a long-detection interval (948 patients; number of intervals to detect arrhythmias programmed at 30–40) or a standard interval (954 patients; 18 of 24 intervals).

The researchers observed a longer time to first overall hospitalization (hazard ratio, 0.81; P=0.01) and cardiovascular hospitalization (hazard ratio, 0.81; P=0.03) for the long-detection group vs. the standard interval group. In addition, there was a reduction in the overall hospitalization rate (52.3 vs. 43.8% per 100 person-years) and length of stay, with no difference in mortality. For overall and cardiovascular hospitalizations, the mean reductions were $299 and $329 per patient-year, respectively, for the long-detection versus standard interval group.

"These favorable results for resource use complement the demonstrated clinical effectiveness of the long-detection interval strategy and come without additional costs for the hospitals or patients," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry; the ADVANCE III study was supported by Medtronic.

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