Liraglutide Linked to Greater Weight Loss Over 56 Weeks in T2DM
(HealthDay News) — For overweight or obese patients with type 2 diabetes, subcutaneous liraglutide (3.0mg) results in more weight loss than placebo over 56 weeks, according to a study published in the August 18 issue of the Journal of the American Medical Association.
Melanie J. Davis, MD, from the University of Leicester in the United Kingdom, and colleagues examined the efficacy and safety of liraglutide vs. placebo in overweight or obese adults with type 2 diabetes. A total of 846 adults from 126 sites were randomized to once-daily subcutaneous liraglutide 3.0mg (423 participants), liraglutide 1.8mg (211 participants), or placebo (212 participants), all as an adjunct to dietary deficit and increased physical activity.
The researchers found that weight loss was 6.0, 4.7, and 2.0%, respectively, for liraglutide 3.0mg, liraglutide 1.8mg, and placebo (P=0.001 for both). Weight loss of ≥5% occurred in 54.3, 40.4, and 21.4%, respectively, of the liraglutide 3.0mg, liraglutide 1.8mg, and placebo groups (P<0.001 for both); the corresponding values for weight loss of ≥10% were 25.2, 15.9, and 6.7% (P<0.001 for liraglutide 3.0mg vs. placebo and P=0.006 for liraglutide 1.8mg vs. placebo).
"Among overweight and obese participants with type 2 diabetes, use of subcutaneous liraglutide (3.0mg) daily, compared with placebo, resulted in weight loss over 56 weeks," the authors write.
Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which funded the study. Liraglutide is a Novo Nordisk proprietary compound.