Levetiracetam Effective for Neuropathic Pain?
the MPR take:
While antipeileptic agents have been used for pain management, the efficacy of levetiracetam for the treatment of neuropathic pain has yet to be reviewed. In a recent study published by the Cochrane Pain, Palliative and Supportive Care Group, researchers investigated whether levetiracetam could be an effective therapy by analyzing studies that compared levetiracetam with placebo or another drug in patients with chronic neuropathic conditions (central pain due to MS, painful polyneuropathy, postherpetic neuralgia, central post-stroke pain, pain following spinal cord injury, and post-mastectomy pain). None of the six studies examined provided enough evidence to show any benefit from levetiracetam in treating pain associated with any of these neuropathic pain conditions. Patients also experienced more adverse effects with the drug and were more likely to withdraw from the study.
Background: Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. The efficacy of levetiracetam for relief of neuropathic pain has not previously been reviewed...