Is Aspirin Effective for Secondary Prevention of Stroke?
the MPR take:
The benefits of long-term aspirin therapy for secondary stroke prevention, where the stroke is of undetermined etiology, may outweigh the risks typically associated with aspirin, says a new study published in the journal Neurology. In 2010, an estimated 11,590,204 strokes were reported in low-and middle-income countries. Using a Markov state transition model, the researchers were able to predict that using aspirin therapy would have led to a yearly decrease of 84,492 recurrent strokes and 4,056 deaths related to stroke. In settings where access to neuroimaging to distinguish between intracerebral hemorrhage (ICH) and ischemic stroke is limited, the use of aspirin therapy for secondary prevention of stroke of undetermined etiology would appear to be a preferred treatment since it is predicted to lead to decreased stroke recurrence and stroke-related death.
Objective: To analyze the potential impact of aspirin therapy for long-term secondary prevention after stroke of undetermined etiology in resource-limited settings without access to neuroimaging to distinguish ischemic stroke from intracerebral hemorrhage (ICH).Methods: We conducted a decision analysis using a Markov state transition model.
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