Increasing Shift From Islet Antibody Positivity to Diabetes
(HealthDay News) − There is an increase in both the prevalence and levels of islet antigen-2 and zinc transporter 8, as well as in autoantibodies, in newly diagnosed type 1 diabetes patients during a period of rising disease incidence.
Anna E. Long, of the University of Bristol in the United Kingdom, and colleagues analyzed autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) by measurement with radioimmunoassay of sera collected from children and young adults with newly diagnosed type 1 diabetes between 1985−2002.
The researchers found that the prevalence of IA-2A and ZnT8A increased significantly over the period studied. This finding was accompanied by raised levels of IA-2A, ZnT8A, and IA-2β autoantibodies (IA-2βA). No changes were observed in IAA or GADA prevalence and levels.
"Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response," the authors write.