Hypoglycemia Ups Cardio Events, Mortality for Insulin-Treated
(HealthDay News) — For insulin-treated patients with type 1 and type 2 diabetes, hypoglycemia is associated with increased risk of cardiovascular events and all-cause mortality, according to a study published online December 9 in Diabetes Care.
Kamlesh Khunti, MBChB, PhD, MD, from the University of Leicester in the United Kingdom, and colleagues conducted a retrospective cohort study using data from the Clinical Practice Research Datalink database for insulin-treated patients with diabetes. The authors examined the correlation between hypoglycemia and the risk of cardiovascular events and all-cause mortality.
The researchers found that the hazard ratios for cardiovascular events in those with type 1 diabetes were 1.51 (95% confidence interval [CI], 0.83–2.75) for those with a history of cardiovascular disease and 1.61 (95% CI, 1.17–2.22) for those without a history of cardiovascular disease before the index date. The hazard ratios were 1.60 (95% CI, 1.21–2.12) and 1.49 (95% CI, 1.23–1.82), respectively, for those with type 2 diabetes. The corresponding hazard ratios for all-cause mortality among those with type 1 diabetes were 1.98 (95% CI, 1.25–3.17) and 2.03 (95% CI, 1.66–2.47), respectively, and 1.74 (95% CI, 1.39–2.18) and 2.48 (95%CI, 2.21–2.79), respectively, for those with type 2 diabetes.
"Hypoglycemia is associated with an increased risk of cardiovascular events and all-cause mortality in insulin-treated patients with diabetes," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.