HTN Risk Up for African-American Live Kidney Donors
(HealthDay News) – African-American live kidney donors have a significantly increased risk of hypertension compared with non-donors.
To examine the risk of hypertension and kidney disease in donors, Mona D. Doshi, MD, of Wayne State University in Detroit, and associates evaluated 103 African-American live kidney donors, who donated between 1993 and 2006 at two transplant centers, and 235 matched non-donors from the Coronary Artery Risk Development in Young Adults prospective cohort study. Donors and non-donors were followed for a mean of 6.8 or 6.4 years, respectively.
The researchers found that donors had a significantly increased hypertension risk compared with non-donors (40.8 vs.17.9%; relative risk, 2.4). Just over half (52.4%) of the donors with hypertension were untreated. Of the donors, 15.5% had an estimated glomerular filtration rate <60mL/min/1.73m², 5.8% had microalbuminuria, and none of them were on dialysis.
"The data from our retrospective study demonstrates that live kidney donation is associated with increased risk of hypertension in African-Americans," the authors write. "At this time, results of the current study should not dissuade African-Americans from being a live kidney donor, but does raise awareness about the importance of donor follow-up."
One of the authors disclosed financial ties to the pharmaceutical industry.