HPV Vaccination, MS Link Explored in Study

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HPV Vaccination, MS Link
HPV Vaccination, MS Link

(HealthDay News) — The quadrivalent human papillomavirus (HPV) vaccine doesn't increase the risk for multiple sclerosis or other demyelinating diseases, according to a new study. The findings appear in the January 6 issue of the Journal of the American Medical Association.

Researchers led by Nikolai Madrid Scheller, MB, of the Statens Serum Institute in Copenhagen, Denmark, examined data on 3,983,824 Danish and Swedish girls and women from 2006–2013. The participants ranged in age from 10–44 years. Using national registers, the researchers analyzed information on HPV vaccination and the diagnoses of multiple sclerosis and similar central nervous system disorders.

Of all the girls and women included in the study, 789,082 received a quadrivalent HPV vaccine over the course of the review period, for a total of 1,927,581 doses. Between 2006–2013, 4,322 of the participants were diagnosed with multiple sclerosis. Of these cases, 73 occurred within the two-year risk period for side effects after vaccination. The researchers also identified 3,300 cases of similar diseases, with 90 occurring within the two-year risk period. In primary and secondary analyses, vaccination was not associated with an increased risk of multiple sclerosis or other demyelinating diseases.

"Our study adds to the body of data that support a favorable overall safety profile of the quadrivalent HPV vaccine and expands on this knowledge by providing comprehensive analyses of multiple sclerosis and other demyelinating diseases," the authors write. They add that, given the size of the study population and the random use of nationwide registry data from Denmark and Sweden, it's likely that the findings are applicable to women in other countries.

The study was funded in part by the Novo Nordisk Foundation; several authors disclosed financial ties to the pharmaceutical industry.

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