How Memantine May Help Recovery in Stroke
the MPR take:
Researchers are investigating whether the drug memantine, typically used to treat Alzheimer's disease, could potentially enhance recovery in patients who have had strokes. The study, published in the journal Stroke, suggests that memantine may work to improve sensory and motor cortical function through improved vascularization, increased brain-derived neurotrophic factor signaling, and reduced reactive astrogliosis. While studies have only been conducted in mice so far, results suggest that memantine may be worth exploring further for this use.
Background and Purpose- Stroke treatment is constrained by limited treatment windows and the clinical inefficacy of agents that showed preclinical promise. Memantine is a well-tolerated N-methyl-D-aspartate glutamate receptor antagonist in common use for Alzheimer disease. Methods- Memantine, 30 ...
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