High Dose Corticosteroids May Reduce Corrosive-Induced Esophageal Strictures

the MPR take:

High doses of a corticosteroid may help reduce esophageal strictures in children who have ingested caustic substances, according to a new study in Pediatrics. In this research, 83 children with grade IIb esophageal burns due to corrosive substance ingestion were administered methylprednisolone (1g/1.73m2 per day for 3 days), ranitidine, ceftriaxone, and total parenteral nutrition or ranitidine, ceftriaxone, and total parenteral nutrition alone. The children receiving methylprednisolone were less likely to develop strictures and had a shorter duration of parenteral nutrition compared to the control group. The high doses of methylprednisolone were well tolerated without any side effects, leading the authors to suggest that it could be effectively used in the management of grade IIb esophageal burns for reducing stricture development.

Corticosteroids Reduce Corrosive-Induced Esophageal Strictures
Corticosteroids Reduce Corrosive-Induced Esophageal Strictures
Our aim was to study the influence of high doses of corticosteroids in preventing esophageal strictures.METHODS: Eighty-three children with a mean age of 4.10 2.63 years and with grade IIb esophageal burns (an esophagogastroscopy was performed within 24-48 hours of injury) due to corrosive substance ingestion were enrolled in our study between 2005 and 2008.

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