Frozen Fecal Samples Efficacy Equal to Fresh Sample in Transplant

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Prepackaged stool samples may be used to combat C. difficile infections
Prepackaged stool samples may be used to combat C. difficile infections

HealthDay News — Frozen stool samples work just as well as freshly donated samples when treating Clostridium difficile infection through fecal transplantation, according to findings published in the January 12 issue of the Journal of the American Medical Association.

Christine Lee, MD, director of the microbiology residency program at McMaster University in Hamilton, Canada, and colleagues randomly assigned 232 C. difficile patients to receive either a frozen or fresh fecal transplantation via enema.

The researchers found that frozen samples cured 83.5% of patients within 13 weeks, compared with 85.1% of patients treated with fresh samples. Further, the researchers noted no serious side effects with either fresh or frozen fecal transplantation.

"Among adults with recurrent or refractory Clostridium difficile infection, the use of frozen compared with fresh fecal microbiota transplantation did not result in worse proportion of clinical resolution of diarrhea," the authors write. "Given the potential advantages of providing frozen fecal microbiota transplantation, its use is a reasonable option in this setting."

Several authors disclosed financial ties to pharmaceutical and biotechnology companies, including Rebiotix.

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