For Men, Obesity in Youth Ups Cardiometabolic Risk by Age 55
(HealthDay News) – Nearly half of young, obese men have an adverse cardiometabolic event or die before age 55 years, according to a study published online April 29 in BMJ Open.
Morten Schmidt, MD, from Aarhus University Hospital in Denmark, and colleagues analyzed data from population-based medical databases for 6,502 men born in 1955 to examine the correlation between body mass index (BMI) in young adulthood with cardiovascular risks before age 55 years. Follow-up continued from the participants' 22nd birthday until death or age 55 years.
The researchers found that 48% of all obese participants (BMI, ≥30kg/m²) died before reaching age 55 years or were diagnosed with type 2 diabetes, hypertension, myocardial infarction, stroke or venous thromboembolism. Comparing obese with normal weight men (BMI, 18.5 to <25kg/m²) correlated with a 28% risk difference for any outcome, and a hazard ratio of 3. Obesity correlated with an event rate that was increased more than eightfold for type 2 diabetes, four-fold for venous thromboembolism, and twofold for hypertension, myocardial infarction and death, compared with normal weight.
"In this cohort of young men, obesity was strongly associated with adverse cardiometabolic events before 55 years of age, including venous thromboembolism," the authors write. "Compared with those of normal weight, young obese men had an absolute risk increase for type 2 diabetes, cardiovascular morbidity or premature death of almost 30%."