Following a Stroke, Long-Term Mortality Rate Rises for Adults

Long-Term Mortality Up for Under-50s With First Stroke
Long-Term Mortality Up for Under-50s With First Stroke

(HealthDay News) – For adults aged 18–50 years with acute stroke, 20-year mortality is higher than expected, according to a study published in the March 20 issue of the Journal of the American Medical Association.

Loes C.A. Rutten-Jacobs, from Radboud University Nijmegen Medical Center in the Netherlands, and colleagues conducted a prospective cohort study of prognosis in 959 consecutive patients, aged 18–50 years, with first-ever transient ischemic attack, ischemic stroke, or hemorrhagic stroke. Participants were followed for a mean of 11.1 years, during which time observed mortality was compared with expected mortality, derived from mortality rates for the general population.

The researchers found that 20% of patients had died at the end of follow-up. Among 30-day survivors, the observed 20-year mortality exceeded expected mortality in the general population for each stroke type (observed vs. expected standardized mortality ratios: 2.6 for transient ischemic attack; 3.9 for ischemic stroke; 3.9 for intracerebral hemorrhage). Among 30-day survivors, the cumulative 20-year mortality was higher in men than women (33.7% vs.19.8%), with standardized mortality ratios of 4.3 and 3.6, respectively. Observed mortality exceeded expected mortality for all etiologic subtypes of ischemic stroke.

"To conclude, among adults aged 18–50 years, 20-year mortality following first acute stroke was relatively high compared with expected mortality," the authors write.

One author disclosed financial ties to Boehringer Ingelheim.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)