Flu Shots Benefit Pregnant Women, With or Without HIV
the MPR take:
The influenza vaccine is effective in preventing confirmed influenza in pregnant women, including those with HIV, reports research in the New England Journal of Medicine. Two double-blind, randomized, placebo-controlled trials studied the trivalent inactivated influenza vaccine (IIV3) in pregnant women in South Africa infected with HIV during 2011-2012 and in pregnant women who were not infected (totaling 2,310 women). The vaccine-efficacy rate was 50.4% for women without HIV and 48.8% for their offspring (monitored until 24 weeks postpartum); the efficacy rate for women with HIV was 57.7%. Because five vaccine and six placebo recipients among offspring born to mothers with HIV developed influenza within 24 weeks of birth, this difference was not considered to be statistically significant. Although the influenza vaccine is not indicated for children <6 months of age, this study indicates that it can benefit pregnant women with a potential protective effect in infants.
There are limited data on the efficacy of vaccination against confirmed influenza in pregnant women with and those without human immunodeficiency virus (HIV) infection and protection of their infants.
READ FULL ARTICLE From New England Journal of Medicine