Fit, Middle-Aged Men Less Likely to Develop Cancer in Later Life

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Cancer Risk Down for Men With High Midlife Fitness
Cancer Risk Down for Men With High Midlife Fitness

(HealthDay News) — Fit middle-aged men appear less likely to develop lung and colorectal cancer in later life than their out-of-shape peers. And if they do develop cancer, they are more likely to beat it, a new study suggests. The report was published online March 26 in JAMA Oncology.

For the study, Susan Lakoski, MD, an assistant professor of medicine at the University of Vermont in Burlington, and colleagues used information from two sources: fitness assessments conducted between 1971 and 2009 when the men averaged 49 years, and Medicare data (on men from age 65 on) from 1999 to 2009.

Over an average of 6.5 years of follow-up, 1,310 of 13,949 men were diagnosed with prostate cancer, 200 with lung cancer, and 181 men with colorectal cancer. The fittest men had a 55% lower risk of lung cancer and a 44% lower risk of colorectal cancer, compared with unfit men, the researchers found. They also had a 32% lower risk of dying if they did develop lung, colorectal, or prostate cancer.

"Men who are physically fit are expected to have lower levels of [cancer-related] sex hormones, enhanced immunity, and lower inflammation," Lakoski told HealthDay. Lakoski stressed that this study shows an association between fitness and protection from cancer, not necessarily a cause-and-effect relationship.

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