First Human Death From Novel H10N8 Virus Reported
(HealthDay News) — A novel reassortant H10N8 virus has been identified in a human patient, according to an article published online Feb 5 in The Lancet.
HaiYing Chen, M.D., from Nanchang City Disease Control and Prevention in China, and colleagues obtained and analyzed clinical, epidemiological, and virological data from a 73-year-old female patient with influenza A H10N8 virus infection.
The researchers found that the patient presented with fever and was admitted to the hospital on November 30, 2013, where she developed multiple organ failure and died nine days after onset of illness. In the tracheal aspirate specimen obtained seven days after illness onset, a novel reassortant avian influenza A H10N8 virus was isolated. Sequence analyses found that all genes of the virus were of avian origin, and six internal genes were from avian influenza A H9N2 viruses. An avian-like receptor binding preference was indicated by the aminoacid motif GlnSerGly at residues 226 to 228 of the hemagglutinin protein. The original tracheal aspirate samples contained a mixture of glutamic acid and lysine at residue 627 in PB2 protein, associated with mammalian adaptation. The virus was found to be sensitive to neuraminidase inhibitors. It was established that the patient had visited a live poultry market four days before onset of illness.
"The virus caused human infection and could have been associated with the death of a patient," the authors write.