Feasibility of Endoscopic Sleeve Gastroscopy in Obese Patients
HealthDay News — For selected patients with obesity, minimally invasive endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and reduces body weight, according to a study published online in Clinical Gastroenterology and Hepatology.
Barham K. Abu Dayyeh, MD, MPH, from Mayo Clinic in Rochester, Minnesota, and colleagues examined the durability of ESG and its effects on body weight and gastrointestinal function in a cohort of 25 obese individuals. Participants underwent ESG with endo-luminal creation of a sleeve along the gastric lesser curve. They were followed for a median of nine months, during which time changes in body weight were measured and adverse events recorded.
The researchers found that at 6, 9, 12, and 20 months after the procedure, subjects had lost 53 ± 17, 56 ± 23, 54 ± 40, and 45 ± 41% of excess body weight, respectively (P < 0.01). All subjects had intact gastroplasty on endoscopy at three months. A decrease in caloric consumption to reach maximum fullness (59%; P = 0.003), slowing of gastric emptying of solids (P = 0.03), and a trend toward increased insulin sensitivity (P = 0.06) were observed in physiologic analyses of four participants after ESG. Serious adverse events were observed in three patients, all of who made full recoveries with no need for surgical interventions.
"ESG could be an alternative to bariatric surgery for selected patients with obesity," the authors write.
Two authors disclosed financial ties to Apollo Endosurgery, which partially funded the study.