Evaluating Idiopathic Membranous Nephropathy with Novel ELISA
the MPR take:
In a study published in the American Journal of Clinical Pathology, a novel ELISA (enzyme-linked immunosorbent assay) was able to effectively differentiate between idiopathic and secondary membranous nephropathy. Serum samples were tested for the presence of anti-PLA2R1 using indirect immunofluorescence, Western blotting test, and ELISA. Both the Western blotting test and indirect immunofluorescence shared high agreement with ELISA.
Objectives: Autoantibodies against the M-type phospholipase A2 receptor 1 (anti-PLA2R1) have been demonstrated to be very specific for idiopathic membranous nephropathy (MN). We studied a novel enzyme-linked immunosorbent assay (ELISA) and compared results with results obtained using an indirect ...
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