Endurance Training Cuts Lipid-Induced Insulin Resistance
(HealthDay News) – Endurance training seems to lessen the effect of lipid-induced insulin resistance, specifically by preventing lipid-induced reduction in nonoxidative glucose disposal (NOGD).
In a study involving nine endurance-trained and 10 untrained subjects, Esther Phielix, from the Maastricht University Medical Center in the Netherlands, and colleagues examined whether high oxidative capacity, seen in endurance-trained athletes, could attenuate lipid-induced insulin resistance. Participants underwent a clamp with infusion of glycerol or intralipid.
The researchers found that trained athletes had significantly higher mitochondrial capacity and insulin sensitivity (~32 and ~22%, respectively). Insulin-stimulated glucose uptake was reduced by lipid infusion by 63% in untrained subjects, and this effect was attenuated in trained subjects (29%). Lipid infusion reduced oxidative and NOGD in untrained subjects, while trained subjects were protected from lipid-induced reduction in NOGD.
"Overall, from the current study, we conclude that chronic exercise training attenuates lipid-induced insulin resistance by preventing a reduction in NOGD," the authors write. "In the future, more mechanistic studies are needed to fully understand the mechanism by which endurance training affects lipid-induced NOGD."