Do IBD Flares Increase MI Recurrence Risk?
the MPR take:
Patients with active inflammatory bowel disease (IBD) have a greater risk of recurrent myocardial infarction (MI) following first-time MI compared to non-IBD patients, reports a new study in Circulation: Cardiovascular Quality and Outcomes. Using national registries in Denmark, 1,030 patients with IBD that were diagnosed with first-time MI between 2002–2011 were identified and categorized according to disease activity stages of flare (120 days), persistent (>120 days) activity, or remission. Compared with non-IBD patients, the odds ratio of death during hospitalization or within 30 days of discharge was 3.29 (95% CI, 1.98–5.45) for patients in IBD flares, 1.62 (95% CI, 0.95–2.77) for persistent activity, and 0.97 (95% CI, 0.78–1.19) for remission. IBD flares were associated with an increased risk of recurrent MI (95% CI, 1.79–5.32), all-cause mortality (95% CI, 1.61–3.15), and a composite end point of recurrent MI, cardiovascular death, and stroke (95% CI, 1.35–3.06) vs. the non-IBD patients; no increased risk was identified in patients in remission. After first-time MI, known risk factors for MI should be assessed in IBD patients with remission as a goal to further reduce recurrent MI risk.
We examined the effect of active IBD on major adverse cardiovascular outcomes after myocardial infarction (MI).Methods and Results- In nationwide registries, we identified 86 790 patients with first-time MI from the period 2002 to 2011. Odds ratio of death during hospitalization or within 30 ...
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