Dietary Elimination Effective for Eosinophilic Esophagitis
(HealthDay News) — Dietary elimination is associated with improvement in symptoms and endoscopic appearance in adults with eosinophilic esophagitis (EoE), according to a study published in the August issue of Clinical Gastroenterology and Hepatology.
W. Asher Wolf, MD, MPH, from the University of North Carolina School of Medicine in Chapel Hill, and colleagues utilized the University of North Carolina EoE database from 2006–2012 to assess the response of adults with EoE to dietary therapy. Thirty-one participants, aged ≥18 years, had undergone dietary therapy with a targeted elimination diet (22 patients) or a six-food elimination diet (SFED; nine patients).
The researchers found that 71% of participants had improvement in symptoms (68% in targeted, 78% in SFED), and 54% experienced improvement in endoscopic appearance (53% in targeted, 56% in SFED). There was a significant decrease in the mean eosinophil count after dietary therapy (P=0.009). Response to dietary therapy was not predicted by clinical, endoscopic, or histologic factors. To identify trigger(s), nine of 11 responders underwent food reintroduction, and reactions were seen to dairy and eggs (four responders each), wheat (two responders), shellfish, legume, and nuts (one responder each).
"Further research should emphasize which factors can predict effective dietary therapy," the authors write.