Depressive Symptoms Tied to Incident T2DM in Black Women
(HealthDay News) — Among African-American women, depressive symptoms and antidepressant use are associated with incident type 2 diabetes, according to a study published online June 5 in Diabetes Care.
Varsha G. Vimalananda, MD, MPH, from the Boston University School of Medicine, and colleagues examined the correlation between depressive symptoms and antidepressant use with incident type 2 diabetes using data from 35,898 women from the Black Women's Health Study. Participants completed the Center for Epidemiologic Studies Depression Scale (CES-D) in 1999 and were followed through 2011.
The researchers identified 3,372 incident diabetes cases over 12 years of follow-up. Compared with a CES-D score of <16, the incidence rate ratios of diabetes were 1.23 (95% confidence interval [CI], 1.12–1.35), 1.26 (95% CI, 1.12–1.41), and 1.45 (95% CI, 1.24–1.69) for CES-D scores of 16–22, 23–32, and ≥33, in a basic multivariate model that included age, time period, family history of diabetes, and education. The incidence rate ratios were attenuated to 1.11 (95% CI, 1.01–1.22), 1.08 (95% CI, 0.96–1.22), and 1.22 (95% CI, 1.04–1.43), after multiple adjustment for lifestyle factors and body mass index (BMI). For antidepressant use, the adjusted incidence rate ratio was 1.26 (95% CI, 1.11–1.43). Similar results were obtained for obese women.
"Both depressive symptoms and antidepressant use are associated with incident diabetes among African-American women," the authors write. "These associations are mediated in part, but not entirely, through lifestyle factors and BMI."