CHD Risk in Diabetes Correlates with BMI Seven Years Earlier
(HealthDay News) — The risk of coronary heart disease (CHD) over seven years increases with higher body mass index (BMI) at baseline among patients with diabetes, with a U-shaped association between BMI at the last visit and the risk of CHD among women, according to a study published online September 23 in Diabetes Care.
Nan Li, M.D., from Pennington Biomedical Research Center in Baton Rouge, LA, and colleagues investigated the association between BMI and CHD risk among type 2 diabetes patients (10,955 men and 19,479 women) aged 30–95 years. Participants were free of CHD and stroke at baseline.
The researchers found that over a mean follow-up of 7.3 years, 7,414 subjects developed CHD. Across BMI levels (18.5–24.9, 25–29.9, 30–34.9, 35–39.9, and ≥40kg/m²) at baseline, the multivariable-adjusted hazard ratios for CHD were 1.00, 1.14 (95% confidence interval [CI], 1–1.29), 1.27 (1.12–1.45), 1.54 (1.34–1.78), and 1.42 (1.23–1.64) in men and 1.00, 0.95 (95% CI, 0.85–1.07), 0.95 (0.84–1.06), 1.06 (0.94–1.2), and 1.09 (1–1.22) in women, respectively. The positive association between BMI and CHD risk did not change in men when the researchers used a mean or last-visit BMI value. In women, however, with use of the last-visit value of BMI, the positive association of BMI with CHD changed to a U-shaped association.
"Our study suggests that there is a positive association between BMI at baseline and during follow-up with the risk of CHD among patients with type 2 diabetes," conclude the authors.