Coffee Ups Prediabetes Risk in Certain Young Adults
the MPR take:
Young adults with hypertension were shown to have an increased risk of prediabetes with moderate and heavy coffee consumption in a new study, contradicting previous research that linked coffee consumption to a lower risk of type 2 diabetes. In the HARVEST (Hypertension and Ambulatory Recording VEnetia STudy) trial, 1,180 patients ages 18–45 with stage 1 hypertension and no diabetes diagnosis were assessed on daily coffee consumption; genotyping of CYP1A2 (the enzyme that metabolizes caffeine) was conducted in 639 patients. Prediabetes was diagnosed in 24% of patients after 6.1 years, with moderate drinkers (1–3 cups/day) having a 34% increased risk and heavy drinkers (>3 cups/day) having twice the risk vs. those who did not drink coffee. However, the risk of prediabetes was increased only in those heavy drinkers slow to metabolize caffeine but not among the fast caffeine metabolizers. The risk was even greater for those who were overweight or obese. Because genotyping may not be available to all young-to-middle-age patients, those with existing risk factors for prediabetes should limit their coffee intake.
Barcelona, Spain - Tuesday 2 September 2014: Coffee increases the risk of prediabetes in young adults with hypertension who are slow caffeine metabolisers, according to results from the HARVEST study presented at ESC Congress today by Dr Lucio Mos from Italy. People who drank more than three cups of coffee per day doubled their risk of prediabetes.
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