Clinical Illness, Outcomes for Ebola in Sierra Leone Reviewed

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Clinical Illness, Outcomes for Ebola in Sierra Leone Reviewed
Clinical Illness, Outcomes for Ebola in Sierra Leone Reviewed

(HealthDay News) — For patients with Ebola virus disease (EVD) from Sierra Leone, the incubation period for is 6–12 days and case fatality 74%, according to a study published online October 29 in the New England Journal of Medicine.

John S. Schieffelin, MD, from Tulane University in New Orleans, and colleagues reviewed records from patients diagnosed with EVD from May 25 to June 18, 2014, in Sierra Leone. In a subgroup of patients, Ebola virus load (EBOV) was assessed using quantitative reverse-transcriptase polymerase chain reaction. Data were available for 107 patients diagnosed with EVD; outcome was known for 87 and detailed clinical information was available for 44.

The researchers found that the estimated incubation period was 6–12 days, and there was a 74% case fatality rate. Fever; weakness; dizziness; diarrhea; and elevated levels of blood urea nitrogen, aspartate aminotransferase, and creatinine at presentation correlated with fatal outcome. A lower case fatality rate was seen for patients <21 years vs. >45 years (57 vs. 94%; P=003). The case fatality rate was also lower for patients presenting with <100,000 EBOV copies/milliliter vs. ≥100,000 EBOV copies/milliliter (33 vs. 94%; P=0.003).

"The incubation period and case fatality rate among patients with EVD in Sierra Leone are similar to those observed elsewhere in the 2014 outbreak and in previous outbreaks," the authors write.

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