Chronic Inflammation Linked to Greater CVD, Diabetes Risk
the MPR take:
Patients with chronic inflammatory disorders like psoriasis, Crohn's disease, and rheumatoid arthritis may have a greater risk of cardiovascular disease and type 2 diabetes, with the risk linked to inflammation severity. This research from the journal Circulation measured new diagnoses of type 2 diabetes, stroke, or coronary heart disease in patients with severe psoriasis, mild psoriasis, bullous skin diseases, ulcerative colitis, Crohn's disease, rheumatoid arthritis, systemic autoimmune disorders, and systemic vasculitis. The highest risks were seen in patients with systemic autoimmune disorders (1.32, CI: 1.16–1.44) and systemic vasculitis (1.29, CI: 1.16–1.44) while risks increased with organ-specific disorders, including severe psoriasis (1.29, CI: 1.12–1.47) and ulcerative colitis (1.26, CI: 1.14–1.40). Patients with the highest severity of inflammation had a greater risk of multiple outcomes compared to those with lower severity.
Methods and Results- A matched cohort study was implemented in the UK Clinical Practice Research Datalink (CPRD) including participants with severe psoriasis (5,648), mild psoriasis (85,232), bullous skin diseases (4,284), ulcerative colitis (12,203), Crohn's disease (7,628), inflammatory arthritis (27,358), systemic autoimmune disorders (7,472), systemic vasculitis (6,283) and 373,851 matched controls.
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