Certain NSAIDS May Up CV Risk in Postmenopausal Women
the MPR take:
Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) in postmenopausal women is associated with an increased risk for cardiovascular events, finds a new study in Circulation: Cardiovascular Quality and Outcomes. 160,801 participants from the Women’s Health Initiative study were analyzed for regular NSAID use and cardiovascular events like cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. Regular NSAID users had a greater risk of cardiovascular events vs. no NSAID used, particularly with use of selective cox-2 inhibitors and nonselective agents with cox-2>cox-1 inhibition. No elevated risk was seen with nonselective NSAIDs with cox-1>cox-2 inhibition.
We hypothesized that regular NSAID use is associated with increased risk for cardiovascular events in postmenopausal women, and that this association is stronger with greater cyclooxygenase (cox)-2 when compared with cox-1 inhibition.Methods and Results- Postmenopausal women enrolled in the Women's Health Initiative were classified as regular users or nonusers of nonaspirin NSAIDs.
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