Cerebrospinal Venous Insufficiency Rare in Multiple Sclerosis
(HealthDay News) – Chronic cerebrospinal venous insufficiency is rarely observed in those with multiple sclerosis, their unaffected siblings, or controls, according to a study published online Oct. 9 in The Lancet.
Anthony L. Traboulsee, MD, from the University of British Columbia in Vancouver, Canada, and colleagues conducted a case-control, multicenter study involving 177 adults to establish the prevalence of venous narrowing in those with multiple sclerosis (79 participants), unaffected full siblings (55 participants), and unrelated healthy volunteers (43 participants). Catheter venography and ultrasound criteria for chronic cerebrospinal venous insufficiency were used to assess narrowing of the internal jugular and azygous veins (data for 149 and 171 participants, respectively).
The researchers found that, based on catheter venography criteria, 2% of those with multiple sclerosis, 2% of siblings, and 3% of unrelated controls were positive for chronic cerebrospinal venous insufficiency (P=1 for all comparisons). More than 50% narrowing of any major vein was seen in 74, 66, and 70%, respectively. The ultrasound criteria for chronic cerebrospinal venous insufficiency were fulfilled by 44% of those with multiple sclerosis, 31% of siblings (P=0.15), and 45% of unrelated controls (P=0.98).
"This study shows that chronic cerebrospinal venous insufficiency occurs rarely in both patients with multiple sclerosis and in healthy people," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.