Can Testosterone Improve Glucose Metabolism in Men with T2DM?
the MPR take:
Does testosterone therapy improve glucose metabolism in men with lowered testosterone and type 2 diabetes? A new study published in the journal Diabetes Care says no. In the trial, 88 men with type 2 diabetes and lowered testosterone were randomized to receive either IM testosterone undecanoate or placebo; the primary outcome measure was insulin resistance by homeostatic model assessment, the secondary measure was glycemic control by HbA1c. Despite a decrease in fat mass, testosterone treatment did not improve insulin resistance or glycemic control. Also, there was no reduction in visceral abdominal adiposity. Based on these results, researchers concluded that in obese men with modest reductions in testosterone and moderately controlled type 2 diabetes, testosterone treatment does not improve glucose metabolism.
OBJECTIVE: To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone. RESEARCH DESIGN AND METHODS: We conducted a randomized, double-blind, parallel, placebo-controlled trial in 88 men with T2D, aged 35-70 years with an HbA1c 8.5% (69mmol/mol), and a total testosterone level, measured by immunoassay, of 12.0nmol/L (346ng/dL).
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