Brain Changes with CVD Seen Before Clinical Manifestation
(HealthDay News) — Brain imaging changes in association with vascular risk factors precede clinical manifestation of cardiovascular or cerebrovascular disease, according to research published in the October 1 issue of JACC: Cardiovascular Imaging.
Joseph I. Friedman, MD, from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a systematic review of imaging studies to examine brain changes in patients with vascular risk factors, but without clinically manifest cardiovascular or cerebrovascular disease or events. Data were reviewed from 77 studies.
The researchers found that for people without symptomatic cardiovascular, cerebrovascular, or peripheral vascular disease, there were independent correlations between the risk factors of hypertension, diabetes mellitus, obesity, hyperlipidemia, and smoking and changes in brain imaging. These changes occurred prior to clinical manifestation of cardiovascular or cerebrovascular disease.
"We conclude that the identification of brain changes associated with vascular risk factors, before the manifestation of clinically significant cerebrovascular damage, presents a window of opportunity wherein adequate treatment of these modifiable vascular risk factors may prevent the development of irreversible deleterious brain changes and potentially alter patients' clinical course," the authors write.
One author disclosed financial ties to the health care industry.