BCS: Radiological Tests Little Use in Detecting Breast Mets
(HealthDay News) – Bone scan, liver ultrasound, and chest radiograph are of little value in staging evaluations of patients with primary breast cancer, according to a study presented at the American Society of Clinical Oncology's annual Breast Cancer Symposium, held from Sept 13–15 in San Francisco.
Stuart-Allison Moffat Staley, from the University of North Carolina at Chapel Hill, conducted a literature review and included eight relevant articles with the primary outcome of detection rates. False-positive and false-negative rates were also reviewed.
The author found that detection rates for bone scan according to stage were: 1.29% for Stage I; 3.09% for Stage II; 2.43% for Stage I and II; and 12.5% for Stage III. For liver ultrasound, detection rates were: 0.47% for Stage I; 1% for Stage II; 0.82% for Stage I and II; and 4.2% for Stage III. Rates for chest radiograph were: 0% for Stage I; 0.42% for Stage II; 0.51% for Stage I and II; and 4.57% for Stage III.
"Our literature analysis suggests that these three tests are of little use in screening women for metastases, and likely result in a lot of false negatives in early-stage disease," Staley said in a statement. "A full picture would require a head-to-head comparison of these radiological tests with more sensitive imaging, such as computed tomography or positron emission tomography."