ASRM: Male Phthalate Levels Linked to Lower Fecundability
(HealthDay News) – Male concentrations of phthalates correlate with diminished couple fecundability, while increased maternal conjugated bisphenol A (BPA) levels correlate with miscarriage, according to two studies presented at the annual meeting of the American Society for Reproductive Medicine, held from Oct. 12–17 in Boston.
In an effort to examine the impact of environmental chemicals on fecundity, Germaine M. Buck Lewis, PhD, from the Eunice Kennedy Shriver National Institute of Child Health & Human Development in Rockville, MD, and colleagues conducted a prospective cohort study involving 501 couples discontinuing contraception in order to become pregnant. The researchers found that female BPA was not associated with diminished fecundity after adjustment for male BPA. In males, concentrations of monomethyl, mono-n-butyl, and monobenzyl phthalates correlated with diminished couple fecundability, with longer time to pregnancy (fecundability odds ratios, 0.8, 0.81, and 0.77, respectively).
To examine the correlation between maternal serum BPA and miscarriage, Ruth B. Lathi, MD, from the Stanford University School of Medicine in California, and colleagues conducted a cohort study involving 114 women presenting for early pregnancy testing. The researchers found that among women with miscarriage vs. those with live births, the median conjugated BPA serum concentration was significantly higher (0.1005 vs. 0.0753 ng/mL). Women with the highest vs. the lowest quartile of serum conjugated BPA had a significantly increased relative risk of miscarriage (1.83) in a pooled analysis.
"Further research on the reproductive effects of environmental endocrine disrupting chemicals is urgently needed," Lathi and colleagues conclude.