Aspirin Use Linked to Age-Related Macular Degeneration
the MPR take:
Age-related macular degeneration (AMD) accounts for up to 50% of all cases of central blindness, and inconsistent results have been reported on its association with aspirin use in previous research. In a meta-analysis of ten studies that included 180,834 individuals, the risk of AMD was associated with aspirin intake but there was no significant association between aspirin use and early or late stage AMD. There was also an association between aspirin use and the development of neovascularization, but not in the subgroup with geographic atrophy. Overall, a weak but statistically significant association between aspirin use and AMD risk was found in the meta-analysis; the exact mechanism of aspirin in the pathophysiology of AMD is unknown, but some theories include aspirin’s role in hypoxia, lipid oxidation, and effects of anticoagulation.
Methods: Relevant studies were searched using databases including PubMed, EMBASE, Cochrane Library and MEDLINE up to March 2014. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated by random-effects or fixed-effect models.
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