ART for All Adults with HIV, Panel Recommends
the MPR take:
The 2014 Recommendations of the International Antiviral Society–USA Panel, published in the Journal of the American Medical Association, advises for the initiation of antiretroviral therapy (ART) for all adults after confirmed diagnosis of HIV infection regardless of CD4 cell count. Based on data and research published since 2012, the year of the previous update, the panel asserts that ART should be initiated as soon as possible to not only treat HIV infection, but also prevent HIV transmission (particularly in pregnant women). Dolutegravir-based regimens and co-formulated elvitegravir/ cobicistat/ tenofovir/ emtricitabine are now included as recommended regimens for initial ART, as is co-formulated rilpivirine/tenofovir/emtricitabine forpatients with HIV-1 RNA levels <100 000 copies/mL. Monitoring of HIV-1 RNA level should be conducted approximately four weeks after treatment initiation or change, followed by every three months to confirm viral suppression and for monitoring of ART toxicity.
Importance: New data and antiretroviral regimens expand treatment choices in resource-rich settings and warrant an update of recommendations to treat adults infected with human immunodeficiency virus (HIV). Recommended initial regimens include 2 nucleoside reverse transcriptase inhibitors (NRTIs; ...
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