Antidepressant May Slow Alzheimer's Progression
the MPR take:
Can an antidepressant slow the progression of Alzheimer’s disease or have a protective effect in healthy individuals? Research published in the journal Science Translational Medicine hints that this could be a small step in the fight against the brain disease. In the study mice with brain damage similar to Alzheimer’s were given citalopram, an SSRI indicated for the treatment of depression. Mice receiving citalopram had a 78% reduction in the appearance of new amyloid-β (Aβ) plaques and their existing amyloid plaques stopped growing compared to placebo. Next, 23 healthy human patients with no diagnosis of depression or brain plaques were given a single dose of citalopram; these subjects had a 37% reduction in normal amyloid production compared to placebo. These results could lead to future research on the use of citalopram as a preventive measure for Alzheimer’s disease.
Tau protein tangles that form in Alzheimer's disease are shown in this image provided by Dr. It's far too early for anyone worried about dementia to try the drug citalopram, which sells as the brand Celexa - and comes with side effects. Alzheimer's is characterized by sticky plaques that form in patients' brains 10 to 15 years before the first memory symptoms are noticed.
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