Anticoagulant Therapy: Comparing Subdural Hematoma Risk
the MPR take:
Vitamin K antagonists (VKAs) such as warfarin may substantially increase the risk of subdural hematoma compared to antiplatelet therapy or direct-acting oral anticoagulants. A review published in the journal Stroke of 19 randomized trials found that the risk of subdural hematoma was significantly higher in patients treated with VKAs compared to antiplatelet therapy, Factor Xa inhibitors, and direct thrombin inhibitors. The authors found that the absolute rate of subdural hematoma among patients with atrial fibrillation treated with VKAs was 2.9 (95% confidence interval, 2.5–3.5) per 1000 patient-years.
Background and Purpose- Subdural hematomas are an important bleeding complication of anticoagulation. We quantify the risk of subdural hematoma associated with anticoagulation with vitamin K antagonists (VKAs) compared with other oral antithrombotic therapies. Methods- Randomized trials were ...
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