Antenatal Corticosteroid Use Up, Even When Not Optimal

Antenatal Corticosteroid Use Up
Antenatal Corticosteroid Use Up

(HealthDay News) — From 1988 –2012, there were increases in the rates of optimal, suboptimal, and questionably appropriate administration of antenatal corticosteroids, according to a study published online January 7 in Obstetrics & Gynecology.

Neda Razaz, MPH, from the University of British Columbia in Vancouver, Canada, and colleagues conducted a population-based study involving all 246,459 live births in Nova Scotia, Canada, from 1988–2012 to examine rates of administration of antenatal corticosteroids. The authors quantified temporal trends in optimal, suboptimal, and questionably appropriate exposure to antenatal corticosteroids.

The researchers found that for neonates born between 28–32 weeks of gestation, there was an increase in the rate of antenatal corticosteroid exposure, from 39.5 % in 1988–1992 to 79.3% in 2008–2012. For those born at 33–34 weeks, exposure increased from 14.3 to 49.7%. There was an increase in receipt of antenatal corticosteroids in optimal cases (from 10% in 1988 to 23% in 2012; odds ratio, 2.7); suboptimal cases (from 7 to 34%; odds ratio, 6.7), and questionably appropriate cases (from 0.2 to 1.7%; odds ratio, 7.5).

"Temporal increases in optimal exposure to antenatal corticosteroids have been matched by increases in suboptimal and questionably appropriate receipt of antenatal corticosteroids, highlighting the need for accurate preterm delivery prognostic models," the authors write.

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