Adipose Tissue Distribution Aids Diabetes Risk Determination
(HealthDay News) – Obese adults with dysfunctional adiposity (excess visceral body fat distribution and insulin resistance) are more likely to develop type 2 diabetes than obese adults with general adiposity, according to a study published in the Sept 19 issue of the Journal of the American Medical Association, a theme issue on obesity.
To identify factors affecting the risk of type 2 diabetes, Ian J. Neeland, MD, from the University of Texas Southwestern Medical Center in Dallas, and colleagues examined body fat distribution, lipids, and markers of insulin resistance and inflammation in 732 obese adults (body mass index of 30kg/m² or greater).
After a median of seven years of follow-up, the researchers found that 11.5% developed diabetes and 39.1% of individuals with normal baseline glucose levels developed prediabetes or diabetes. After controlling for a number of factors, higher baseline visceral fat mass, fructosamine level, fasting glucose level, family history of diabetes, systolic blood pressure, and weight gain over follow-up were associated with a higher risk of diabetes
"In a multiethnic, population-based sample of obese adults, a dysfunctional adiposity phenotype, characterized by excess visceral fat and insulin resistance, identified obese individuals at risk for prediabetes and diabetes, whereas markers of general adiposity did not," Neeland and colleagues conclude.
Two authors disclosed financial ties to pharmaceutical companies. Biomarker measurements were supported by grants from Alere and Roche Diagnostics.