AACR: HPV Genotype Distribution Varies With Race
(HealthDay News) – Human papillomavirus (HPV) genotype distribution seems to vary with race, according to a study presented at the American Association for Cancer Research's International Conference on Frontiers in Cancer Prevention Research, held from Oct. 27–30 in National Harbor, MD.
Adriana C. Vidal, PhD, from the Duke University School of Medicine in Durham, NC, and colleagues describe HPV genotypes in a multi-ethnic cohort of 516 women undergoing colposcopic evaluation following an abnormal liquid-based cytology screen.
The researchers found that 72% of the women were HPV-positive; 37% had no cervical intraepithelial neoplasia (CIN), and 47%, 10%, and 6%, respectively, had CIN1, CIN2, and CIN3. Among CIN1 cases, the most frequent high-risk HPV genotypes were 16, 18, 31, 45, 52, 56, 59, and 66 in white women, and 33, 35, 58, and 68 in African-American women. Among women with CIN2-3, the most common high-risk HPV genotypes were 16, 18, 33, 35, 39, and 59 in white women, and 31, 45, 51, and 66 in African-American women.
"Although our findings need to be replicated in larger cohorts of women, they suggest that the currently available HPV vaccines, which target HPV subtypes 16 and 18 in order to prevent cervical cancer and precancerous cervical abnormalities, will be less beneficial for African-American women than non-Hispanic white women," a coauthor said in a statement.