A Review of Zolmitriptan for Migraine Attacks
the MPR take:
A review of the drug zolmitriptan shows that it is an effective treatment option for patients suffering from migraine attacks. Based on data collected from 25 studies, researchers were able to conclude that this triptan was more effective than placebo, and that the 2.5mg and 5mg dosage strengths of zolmitriptan provided headache relief to the same proportion of people as oral sumatriptan 50mg. The therapeutic activity of zolmitriptan for the treatment of migraine headache is thought to be due to the agonist effects at the (5-HT)1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.
Zolmitriptan is an abortive medication for migraine attacks, belonging to the triptan family. Most of the data were for the 2.5 mg and 5 mg doses compared with placebo, for treatment of moderate to severe pain. For oral zolmitriptan 2.5 mg versus placebo, the NNTs were 5.0, 3.2, 7.7, and 4.1 for ...
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