4.4 mmol/L Is Optimal Fasting Glucose Cutoff for GDM Screening
(HealthDay News) – A fasting plasma glucose value of 4.4mmol/L is the optimal cut point for determining which pregnant Chinese women need a 75-g 2-h oral glucose tolerance test offered at 24–28 weeks' gestation, according to a study published online March 27 in Diabetes Care.
Wei-Wei Zhu, MD, from Peking University First Hospital in China, and colleagues analyzed the medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) from 24,854 pregnant women without known pre-gestational diabetes mellitus (pre-GDM).
The researchers found that a fasting plasma glucose cutoff value of 5.1mmol/L identified 3,149 pregnant women (12.1%) with GDM. A fasting plasma glucose cutoff value of 4.4mmol/L ruled out GDM in 15,369 women (38.2%) women, which would miss 12.2% of patients with mild GDM. The positive predictive value is 0.322, and the negative predictive value is 0.928.
"Fasting plasma glucose at 24–28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions," the authors write.