115-Year-Old Woman's Genes Reveal Clues About Longevity

the MPR take:

Can the genes of a woman who lived to the age of 115 provide insight into longevity? Yes, says a new study published in the journal Genome Research. The woman was the oldest person in the world when she died in 2005 and is believed to be the oldest person in history to donate their body to science. Researchers discovered that her healthy white blood cells contained more than 400 genetic mutations that were tolerated and not disease-causing. The telomeres of her white blood cells were also very short, which the authors hypothesize could indicate that hematopoietic stem cells may have died from 'stem cell exhaustion." Additional research could further probe if stem cell exhaustion is a cause of mortality in very elderly individuals.

115-Year-Old Woman's Genes Reveal Clues About Longevity
115-Year-Old Woman's Genes Reveal Clues About Longevity

More than 400 mutations were found in the healthy white blood cells of a 115-year-old woman, according to a new study that may advance what is known about limits of the human life span. Blood is continually replenished by hematopoietic (meaning "to make blood") stem cells that are inside the ...

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