MAXIPIME
Generic Name for MAXIPIME
Cefepime (as HCl) 500mg, 1g, 2g; pwd for IV infusion or IM inj after reconstitution.
Legal Classification:
Rx
Pharmacological Class for MAXIPIME
Cephalosporin.
Manufacturer of MAXIPIME
Elan Pharmaceuticals
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Indications for MAXIPIME
Susceptible infections, including moderate-to-severe pneumonia, uncomplicated skin and skin structure infections, complicated and uncomplicated urinary tract infections (UTIs) including pyelonephritis, complicated intraabdominal in adults (w. metronidazole). Empiric therapy in febrile neutropenia.
Adult dose for MAXIPIME
When giving IV, infuse over 30 minutes. Pneumonia: 1–2g IV every 12 hrs for 10 days. Skin and skin structures, severe UTIs: 2g IV every 12 hrs for 10 days. Mild-to-moderate UTIs: 500mg–1g IV or IM every 12 hrs for 7–10 days (IM only for UTIs caused by E. coli). Intraabdominal (use w. metronidazole): 2g IV every 12 hrs for 7–10 days. Febrile neutropenia: 2g IV every 8 hrs for 7 days or until neutropenia resolves. CrCl ≤60mL/min: reduce dose; see literature. Hemodialysis: repeat initial dose after each session. Continuous ambulatory peritoneal dialysis: give usual doses at 48-hour intervals.
Children's dosing for MAXIPIME
<2months: not recommended. Not for use in serious infection when pathogen is or may be H. influenzae type b. 2months–16yrs (≤40kg): 50mg/kg per dose, given every 12 hrs; do not exceed recommended adult dose. Severe UTIs, pneumonia, skin and skin structure: give IV for 10 days. Mild-to-moderate UTIs: give IV or IM for 7–10 days (IM only for UTIs caused by E. coli). Febrile neutropenia: give IV every 8 hours for 7 days or until neutropenia resolves.
Contraindications for MAXIPIME
Penicillin or other β-lactam allergy.
Warnings/Precautions for MAXIPIME
Renal impairment. Renal or hepatic dysfunction, poor nutritional state, prolonged antimicrobial therapy: monitor prothrombin time. History of GI disease (esp. colitis). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Interactions for MAXIPIME
Aminoglycosides may potentiate oto- or nephrotoxicity. Possible nephrotoxicity with diuretics (eg, furosemide). May cause false (+) Coomb's, Clinitest.
Adverse Reactions for MAXIPIME
Local reactions (eg, pain, phlebitis, inflammation), rash, GI disturbances, pruritus, fever, headache, seizures, encephalopathy, blood dyscrasias, anemia, renal dysfunction, others.
How is MAXIPIME supplied?
Vials (500mg, 1g, 2g)—10
Related Disease:
Infections, bacterial~systemic antiinfectives
Pneumonia