MARINOL CIII

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MARINOL

Anorexia/cachexia
Nausea
Only 4 drugs may be compared at once

Generic Name and Formulations:

Dronabinol 2.5mg, 5mg, 10mg; caps; contains sesame oil.

Company:

AbbVie

Select therapeutic use:

Indications for MARINOL:

Anorexia with weight loss in AIDS patients.

Adult:

Individualize. Initially 2.5mg twice daily before lunch and supper. If intolerable, may reduce to 2.5mg once in the evening. May increase gradually to max 20mg/day in divided doses.

Children:

Not recommended.

Warnings/Precautions:

Seizure or cardiac disorders. History of psychiatric disorders (eg, mania, depression, schizophrenia) or substance abuse. Write ℞ for smallest practical amount. Keep patient under responsible adult supervision (esp. when dose is adjusted). Children. Elderly (monitor: esp. with dementia). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with benzodiazepines, barbiturates, alcohol, other CNS depressants and other psychoactive substances (avoid). May affect, or be affected by other drugs that are highly protein bound (eg, sympathomimetics, anticholinergics, tricyclic antidepressants). Antagonizes theophylline.

Pharmacological Class:

Cannabinoid.

Adverse Reactions:

Psychomimetic reactions, euphoria, depression, behavior disorders, drowsiness, dizziness, fatigue, somnolence, altered mental status, seizures (discontinue if occurs), ataxia, anxiety, paresthesia, tachycardia, hypotension, vasodilation, tolerance and withdrawal syndrome.

How Supplied:

Caps—60

MARINOL 2.5mg capsules (Qty:60)

appx. price $677.00

Indications for MARINOL:

Refractory nausea and vomiting associated with cancer chemotherapy.

Adults and Children:

Individualize. Initially 5mg/m2 1–3 hrs before chemotherapy. Then every 2–4 hrs after chemo; max 4–6 doses daily. May increase if needed by increments of 2.5mg/m2; max dose 15mg/m2.

Warnings/Precautions:

Seizure or cardiac disorders. History of psychiatric disorders (eg, mania, depression, schizophrenia) or substance abuse. Write ℞ for smallest practical amount. Keep patient under responsible adult supervision (esp. when dose is adjusted). Children. Elderly (monitor: esp. with dementia). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with benzodiazepines, barbiturates, alcohol, other CNS depressants and other psychoactive substances (avoid). May affect, or be affected by other drugs that are highly protein bound (eg, sympathomimetics, anticholinergics, tricyclic antidepressants). Antagonizes theophylline. Phenothiazines may potentiate effect without additional toxicities.

Pharmacological Class:

Cannabinoid.

Adverse Reactions:

Psychomimetic reactions, euphoria, depression, behavior disorders, drowsiness, dizziness, fatigue, somnolence, altered mental status, seizures (discontinue if occurs), ataxia, anxiety, paresthesia, tachycardia, hypotension, vasodilation, tolerance and withdrawal syndrome.

How Supplied:

Caps—60

MARINOL 2.5mg capsules (Qty:60)

appx. price $677.00