Malaria

Novel Malaria Drug Gets Orphan Drug Designation

By November 07, 2017

s well as malaria, they are also evaluating Artemisone for the treatment of human cytomegalovirus (CMV) infections, including stem cell transplant CMV and congenital CMV.

Climate Change Is Real and so Are the Health Threats, Experts Warn

February 21, 2017

Additional 250,000 deaths/year projected from heat stress, malnutrition, infectious diseases

Experimental Malaria Vaccine Shows Favorable Long-Term Protection

By May 10, 2016

Results from a Phase 1 trial published in Nature Medicine show that an investigational malaria vaccine demonstrated durable protection in healthy, malaria-naive adults in the U.S. from infection for >1 year post-immunization.

Malaria Therapy May Also Protect Pregnant Women and Their Fetuses

March 10, 2016

A combination drug therapy widely used to treat malaria in adults - dihydroartemisinin-piperaquine (DP) - also protects pregnant women and their fetuses from the disease.

Genetics Could Explain Malaria Vaccine Response

October 23, 2015

Among children 5 to 17 months, vaccine efficacy higher with matched circumsporozoite protein alleles

Daraprim Alternative Announced in Response to Price Hike

By October 23, 2015

Imprimis Pharmaceuticals announced that it has made available a compounded formulation of pyrimethamine and leucovorin as a lower-cost alternative to Daraprim (pyrimethamine; Turing Pharmaceuticals).

Nobel Prize Awarded for Groundbreaking Research on Infectious Disease Drugs

By October 05, 2015

The Nobel Assembly at Karolinska Institutet has awarded the 2015 Nobel Prize in Physiology or Medicine to researchers for their discoveries concerning novel therapies against infections caused by roundworm parasites and malaria.

Criticism Sparks Cost Reduction in Toxoplasmosis Pill

By September 23, 2015

Turing Pharmaceuticals has agreed to reduce the cost of its drug Daraprim (pyrimethamine) after receiving significant criticism due to a sudden increase in the price of the medication.

Metabolic Syndrome Common in Young Women With Lupus

September 17, 2015

Antimalarial protects against metabolic syndrome, countering steroid effects.

Investigational Malaria Drug Could Be One-Dose Tx

By July 17, 2015

An investigational enzyme inhibitor may be able to cure malaria in a single dose when used in conjunction with another drug, and also be utilized as a preventative treatment.

Why Malaria Drugs Could Be the Future for Parkinson's Disease

By July 16, 2015

Anti-malarial drugs may be a potential treatment option for Parkinson's disease, according to researchers from Nanyang Technological University, McLean Hospital, and Harvard Medical School.

Imperfect Drug Penetration May Accelerate Pathogen Resistance

By May 20, 2015

A pathogen can develop resistance faster in a "pocket" of the body where only one drug is present compared to where no pockets exist, a new study published in the Proceedings of the National Academy of Sciences has shown.

Hydroxychloroquine Daily Dosing Often Exceeds Safety Guidelines

May 05, 2015

Many patients prescribed hydroxychloroquine exceed the safety guidelines for daily dosing, according to a study presented at the annual meeting of the Association for Research in Vision and Ophthalmology.

New Government Policies on Pathogen Research Issued, But Will They Be Effective?

September 25, 2014

New policy guidelines issued by the White House Office of Science and Technology Policy are calling for U.S. universities to carefully monitor their life sciences research on dangerous pathogens and toxins for both benefits and risks.

Increasing Malarial Drug Resistance a Growing Threat

July 31, 2014

The parasite that causes malaria is growing increasingly resistant to the drugs commonly used to fight it, according to new surveillance reports.

Mylan Launches Generic Malarone

May 29, 2014

Mylan announced it has received final approval for its Abbreviated New Drug Application (ANDA) for Atovaquone and Proguanil HCl Tablets, the generic version of GlaxoSmithKline's Malarone.

Potential Vaccine for Pediatric Malaria ID'd

May 22, 2014

Scientists have identified an antigen, PfSEA-1, that generates antibodies hindering the ability of malaria parasites to multiply. Results of this research are published in the journal Science.

CDC: Malaria Cases Reach Record High in 40 Years

October 31, 2013

According to data published in a supplement of the CDC's Morbidity and Mortality Weekly Report (MMWR), there were 1,925 malaria reported in the U.S. in 2011, a 14% increase since 2010.

Malaria Vaccine Highly Protective in Early Trial

August 09, 2013

U.S. researchers announced promising results from a Phase 1 clinical trial of Sanaria's PfSPZ Vaccine to combat malaria.

Antimalarial Linked to Neurologic, Psychiatric Effects

July 29, 2013

The FDA has approved label changes for mefloquine HCl, including a boxed warning regarding serious neurologic and psychiatric side effects.

Malaria Patient Information Fact Sheet

June 28, 2013

This patient information fact sheet provides information on the definition, causes, symptoms, treatments, and preventative measures for malaria.

Efficacy of Pediatric Malaria Vaccine Declines With Time

March 21, 2013

A pediatric malaria vaccine is effective in reducing episodes of clinical malaria, but its efficacy declines precipitously within four years.

Malaria Drug Association With Hemolytic Anemia Unclear

January 11, 2013

Artesunate, a drug used in the treatment of severe malaria, may or may not be associated with hemolytic anemia, so the U.S. Centers for Disease Control and Prevention recommends close monitoring of patients treated with the drug for four weeks after administration of the agent.

Mylan Launches Generic Qualaquin Capsules

December 18, 2012

Mylan announced that the FDA has approved its Abbreviated New Drug Application (ANDA) for Quinine Sulfate Capsules, the generic version of Mutual Pharmaceutical's Qualaquin.

IAVC: Vaccine Offers Modest Malaria Protection to Infants

November 09, 2012

For infants, vaccination with the RTS,S/AS01 vaccine, coadministered with Expanded Program on Immunization (EPI) vaccines, is associated with modest protection against clinical and severe malaria.

Program to Up Access to Combo Malaria Therapy Successful

October 31, 2012

Implementation of a series of national-scale pilot programs designed to increase the access and use of quality-assured artemisinin-based combination therapies (QAACTs) for malaria by the Affordable Medicines Facility-malaria (AMFm) has improved the availability, price, and market share of QAACTs.

Resistant Malaria Increasing on Thailand-Myanmar Border

April 06, 2012

From 2001-2010, an increase was seen in artemisinin resistance in Plasmodium falciparum (P. falciparum) on the Thailand-Myanmar border, which was largely attributable to parasite genetics.

New Combination Malaria Treatment Equally Effective

April 05, 2012

Fixed-dose, combination pyronaridine-artesunate treatment is as effective as mefloquine plus artesunate in treating malaria infection.

Global Malaria Deaths Higher Than Previously Thought

February 03, 2012

Malaria kills more people each year than previously recognized -- nearly 1.2 million people worldwide -- with more than 40% of deaths occurring in older children and adults.

Phase 3 Trial of RTS,S Malaria Vaccine

October 19, 2011

GlaxoSmithKline announced positive results from its ongoing Phase 3 trial of its malaria vaccine candidate RTS,S.